Identification of a CpG Island Methylator Phenotype in Adrenocortical Carcinomas
نویسندگان
چکیده
منابع مشابه
CpG island methylator phenotype in colorectal cancer.
Aberrant methylation of promoter region CpG islands is associated with transcriptional inactivation of tumor-suppressor genes in neoplasia. To understand global patterns of CpG island methylation in colorectal cancer, we have used a recently developed technique called methylated CpG island amplification to examine 30 newly cloned differentially methylated DNA sequences. Of these 30 clones, 19 (...
متن کاملThe CpG island methylator phenotype (CIMP): What’s in a name?
Depts. of a Epidemiology and b Pathology, GROW-School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands; c; Dept. of Mathematical Modeling, Statistics and Bioinformatics, Ghent University, Ghent, Belgium; d; Dept. of Surgery, Orbis Medical Center, Sittard-Geleen, the Netherlands; e ; Dept. of Pathology, Leiden University Medical Center, Le...
متن کاملThe CpG island methylator phenotype: what's in a name?
Although the CpG island methylator phenotype (CIMP) was first identified and has been most extensively studied in colorectal cancer, the term "CIMP" has been repeatedly used over the past decade to describe CpG island promoter methylation in other tumor types, including bladder, breast, endometrial, gastric, glioblastoma (gliomas), hepatocellular, lung, ovarian, pancreatic, renal cell, and pros...
متن کاملPrognostic Significance of CpG Island Methylator Phenotype in Colorectal Cancer
which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Colorectal cancer (CRC) is one of the major causes of cancer-related morbidity and mortality worldwide. Despite of recent advances of variable therapeutic techniques in CRC, cancer progression and metastasis remain the major contributors to cancer-related mo...
متن کاملThe CpG island methylator phenotype (CIMP) in colorectal cancer
It is clear that colorectal cancer (CRC) develops through multiple genetic and epigenetic pathways. These pathways may be determined on the basis of three molecular features: (i) mutations in DNA mismatch repair genes, leading to a DNA microsatellite instability (MSI) phenotype, (ii) mutations in APC and other genes that activate Wnt pathway, characterized by chromosomal instability (CIN) pheno...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2013
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2012-2993